beta agonists relax bronchiole smooth muscle
Summary of bronchiole tone
Side effects of beta-adrenoceptor agonists
• Skeletal muscle tremor
• Cardiac tachycardia-tachyarrhythmias
• Modest prolongation of the QTc interval
• Tachyphylaxis
• Hypokalemia.
• Nausea, vomiting, headache
Side effects of theophylline
• positive chronotropic and inotropic effect.
• Mild cortical arousal.
• Stimulates secretion of gastric acid and digestive enzymes.
• can cause hypokalemia, hyperglycemia, skeletal muscle tremors
• Can cause seizure- related to blood levels
• Can cause tachyarrhythmias
Side effects of glucocorticoids
• Linked to route and dosage
• Glucose intolerance, immunosuppression , bone demineralization, increase in weight, increased bp, decreased growth rate (children).
• Suppression of Adreno-pituitary axis (after 2 wks) with parenteral or oral. (use alternative day therapy)
• Throat thrush, oral hoarseness (inhaled preparations). can increase opportunistic infections
• daily therapy for mild persistent asthma or short, intermittent courses of inhaled or oral
corticosteroids
N Engl J Med. 2005 Apr 14;352(15):1519-28.
