Lung Cancer Image

Lung Cancer, CT scan with 3D reconstruction, presents dry cough and left chest pain.

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Licorice

Stewart et al.4 have proposed that licorice acts by inhibiting Cortisol oxidase, a component of the widely distributed 11β-hydroxysteroid dehydrogenase system that converts Cortisol to cortisone, producing a state of apparent mineralocorticoid excess similar to that in children with 11/3-hydroxysteroid dehydrogenase deficiency5 (Fig. 1FIGURE 1Overview of Cortisol Metabolism.). In vitro, cortisol has the same binding affinity for mineralocorticoid receptors as aldosterone,6whereas that of cortisone is much less. Licorice, by inhibiting 11β-hydroxysteroid dehydrogenase in aldosterone-responsive tissues such as the kidney, where it is found in high concentrations,7 , 8 produces high renal levels of cortisol, which then binds to and activates mineralocorticoid receptors.4 The degree to which licorice inhibits 11β-hydroxysteroid dehydrogenase activity can be measured by examining the ratio of the metabolites of cortisone to those of cortisol in urine.