Wednesday, March 19, 2014

muscle types; endothelin; pulse pressure



no troponin in smooth muscle.  Calcium binds to calmodulin, activates MLCK, phosphorylation triggers actin-myosin crossbridge = contraction.

Beta agonists lead to increased cAMP which inhibits MLCK = relaxation.  Same receptor but opposite effects on vascular and cardiac muscle.


Viagra targets  PDE5  Mainly in groin and lungs.

Good reference for this stuff


Part 2:  Endothelium

ET-1  most potent vasoconstrictor of any




compliance = delta Vol/delta P

pulse pressure = delta P    stroke volume = delta V

pulse pressure = stroke volume/compliance

decreased compliance (aterosclerosis) = increased pulse pressure



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