no troponin in smooth muscle. Calcium binds to calmodulin, activates MLCK, phosphorylation triggers actin-myosin crossbridge = contraction.
Beta agonists lead to increased cAMP which inhibits MLCK = relaxation. Same receptor but opposite effects on vascular and cardiac muscle.
Viagra targets PDE5 Mainly in groin and lungs.
Good reference for this stuff
Part 2: Endothelium
ET-1 most potent vasoconstrictor of any
compliance = delta Vol/delta P
pulse pressure = delta P stroke volume = delta V
pulse pressure = stroke volume/compliance
decreased compliance (aterosclerosis) = increased pulse pressure
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