transport in kidney
Filtered Load = GFR x plasma concentration
- Transport maximum = max filtered load that nephron can reabsorb = 375 mg/min for glucose
HCO3 reabsorption in proximal tubule
- can't cross cell membrane (neg chg)
- combines with H+ to form CO2 & H2O
- CO2 = non-polar molecule = diffuses across membrane
Clearance Ratios
• Comparison of clearance of various solutes to clearance of Inulin
• Why inulin?
• Cx/Cinulin = 1.0
– Substance can be used as a filtration marker
– Not reabsorbed, secreted or metabolized: creatinine
• Cx/Cinulin < 1.0
– Either the substance is not filtered OR it is filtered and subsequently reabsorbed: glucose
• Cx/Cinulin > 1.0
– Substance is filtered (or not) and secreted: organic acids
– Penicillin!
Proximal Tubule
67% of Na and H2O reabsorption
Loop of Henle
Early Distal Tubule
Late Distal Tubule
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